Ms And Mesenchymal Stem Cells

Mesenchymal stem cells showed effects on innate and adaptive immunity in studies on animal models of multiple sclerosis.

Ms and mesenchymal stem cells.

Autologous bone marrow transplantation for the treatment of multiple sclerosis. Mesenchymal stem cells are adult stem cells found in several places in the body including the bone marrow skin and fat tissue. Mark freedman ottawa hospital research. Hscs are capable of producing all of the cells that make up the blood and the immune system.

Read about other types of stem cells. They can produce many different types of cells including muscle and cartilage. Current neurology and neuroscience reports 2014 14 9 478. Mesenchymal stem cells mscs are found in many parts of the body and are usually taken from bone marrow skin and fat tissue.

They produce cells which help other stem cells function properly. Stem cells and ms multiple sclerosis ms is an inflammatory disease of the central nervous system cns with a strong degenerative component leading to irreversible disability. Mesenchymal stem cells mscs also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types including osteoblasts bone cells chondrocytes cartilage cells myocytes muscle cells and adipocytes fat cells which give rise to marrow adipose tissue. Radaelli m et al.

Mesenchymal stem cells mesenchymal stem cells msc are found in many places in the body including the bone marrow skin and fat. Transplanting patients own mesenchymal stem cells mscs is a safe therapeutic approach and can delay disease progression in people with multiple sclerosis ms a meta analysis review shows. Mesenchymal stem cells mscs represent an attractive alternative to develop a cell based therapy for multiple sclerosis. The discovered potential of mesenchymal stem cells msc in treating multiple sclerosis ms has culminated in the launch of mescams mesenchymal stem cell therapy for canadian ms patients a phase ii clinical trial that is funded in part by the ms scientific research foundation research manitoba and a w food services of canada inc.

Most of the reported trials were uncontrolled open label phase i studies and included secondary progressive ms progressive ms relapsing remitting and secondary progressive ms and active but unspecific patients a phase ii trial on secondary progressive ms. The development of hematopoietic and mesenchymal stem cell transplantation as an effective treatment for multiple sclerosis. Hscs haematopoietic stem cells adult stem cells that are found in bone marrow and blood. Many types of stem cells are being explored for their potential benefits for treating multiple sclerosis.

American journal of stem cells 2013 2 2 95 107.